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MediFocus: Future of Molecular Imaging

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NEW YORK, Sept. 11, 2013 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue:

MediFocus: Future of Molecular Imaging http://www.reportlinker.com/p01623036/MediFocus-Future-of-Molecular-Imaging.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Medical_Imaging

MediFocus: Future of Molecular Imaging

Summary

Molecular imaging is at the frontier of diagnostic imaging. It is a vast and multi-disciplinary field that consists of a range of techniques, allowing imaging of various organs and sites within the body with specific targeted probes. Molecular imaging can be defined as ''the visualization, characterization and measurement of biological processes at the molecular and cellular levels in human and other living systems''. Although sluggish economic growth has hindered the growth of the molecular imaging market right from its inception in the leading economies of the world such as in the United States and Europe, the market has attracted attention from both academia and manufacturers in recent years. The need for less invasive imaging techniques and more specific imaging probes has fuelled continued development and ever-changing market competition with molecular imaging.

GlobalData has released its medical device report, "MediFocus: Future of Molecular Imaging". The report offers a comprehensive analysis of the molecular imaging market, including new imaging techniques and late-stage imaging probes. Included within is an analysis of companies currently active in the field with their commercial positioning and portfolio assessment. The report identifies and evaluates key trends and advances shaping the global molecular imaging market, highlighting testimonials from top physicians around the world. The report provides insight into the market opportunities, barriers and drivers within the market for the benefit of new companies willing to enter this market in the near future. This report was built using data and information sourced from proprietary databases, primary and secondary research and in-house analysis by GlobalData's team of diagnostic imaging experts.

Scope

- An overview of the molecular imaging landscape - Investigation of current and future market competition for molecular imaging - Pipeline assessment with product profiles, SWOT analysis and commercial positioning - Evaluation of technology trends in molecular imaging and physician perception - Coverage of key market players with portfolio assessment and SWOT analysis - Direct quotes from Key Opinion Leaders (KOL) currently using and developing molecular imaging probes

Reasons to buy

- Understand the trends shaping and driving the molecular imaging markets - Drive revenues, formulate effective sales and marketing strategies, and gain in-depth understanding of the competitive landscape - Assess competitiveness of products in market by understanding the strengths and weaknesses of current competition - Take a comprehensive look at the market's late-stage probe pipeline and identify promising, paradigm-shifting products - Create an effective counter-strategy to gain a competitive advantage against those currently in the market - Organize your sales and marketing efforts by identifying the market categories and segments that present the best opportunities for growth - What's the next big thing in the global molecular imaging market? Identify, understand and capitalize1 Table of Contents1 Table of Contents 61.1 List of Tables 131.2 List of Figures 162 Introduction 182.1 Catalyst 182.2 Related Reports 183 Overview 19

3.1 What is Molecular Imaging? 193.2 What are Molecular Imaging Probes? 203.3 Growth of Molecular Imaging 213.4 Imaging Techniques 223.4.1 Overview 223.4.2 Positron Emission Tomography (PET) 243.4.3 Single Photon Emission Computed Tomography (SPECT) 303.4.4 Computed Tomography 323.4.5 Magnetic Resonance Imaging 333.4.6 Ultrasound Imaging 353.4.7 Other Emerging Techniques 373.5 Applications of MI 393.5.1 Overview 393.5.2 Oncology 393.5.3 Cardiology 413.5.4 Neurology 424 Unmet Needs Analysis 434.1 Overview 434.2 Radiation Exposure 434.3 Instrumentation Improvement 444.4 Lack of Multidisciplinary-Trained Professionals 454.5 Standardization 465 Market Opportunity Analysis 485.1 Probes for Image-Guided Surgery 485.2 Gallium-68 495.3 Low-Cost PET Systems 505.4 Molecular Imaging in Infectious Disease 52

5.5 Hybrid Imaging 535.6 Longer-Lived Isotopes 555.7 Role of Imaging Probes in Drug Development 566 Market Drivers and Barriers 586.1 Overview 586.2 Driver: Increased Prevalence of Diseases 586.3 Driver: Enthusiasm Surrounding Personalized Medicine 596.4 Driver: Hyperpolarized MRS with 13C Holds Promise 596.5 Driver: MI Applied to Drug Discovery and Development 606.6 Barrier: Regulatory Burden 616.7 Barrier: Cost 636.8 Barrier: Reimbursement 646.9 Barrier: Imaging Probe Production and Distribution Network 656.10 Barrier: Predicted 99mTc Shortage 676.11 Barrier: Reduced Hospital Budgets 686.12 Barrier: Limited Practical Value of Diagnostics in the Absence of Therapeutics 686.13 Barrier: Increased Consciousness Regarding Radiation Dose 717 Imaging Probes Assessment 737.1 Overview 737.2 Small Molecules 747.2.1 Overview 747.2.2 SWOT Analysis 757.2.3 [18F]Fluoro-2-deoxy-2-D-glucose ([18F]FDG) 757.2.4 3'-Deoxy-3'-[18F]fluorothymidine ([18F]FLT) 797.2.5 [18F]Fluoromisonidazole ([18F]FMISO) 827.2.6 1-(5-[18F]Fluoro-5-deoxy-?-D-arabinofuranosyl)-2-nitroimidazole ([18F]FAZA) 857.2.7 L-3,4-Dihydroxy-6-[18F]fluorophenylalanine ([18F]FDOPA) 887.2.8 [18F]Sodium flouride ([18F]NaF) 907.2.9 [11C]Acetate 937.2.10 N-Methyl-[11C]-2-(4'-methylaminophenyl)-6-hydroxybenzothiasole ([11C]PiB) 967.3 Peptides 997.3.1 Overview 997.3.2 SWOT Analysis 1007.4 Nanoparticles 1007.4.1 Overview 100

7.4.2 Types of Nanoparticles for Molecular Imaging 1017.4.3 SWOT Analysis 1027.5 Engineered Proteins 1037.5.1 Overview 1037.5.2 SWOT Analysis 1047.6 Aptamers 1047.6.1 Overview 1047.6.2 SWOT Analysis 1058 Probes Pipeline Assessment 1068.1 Overview 1068.2 [18F]flurpiridaz (Lantheus Medical Imaging) 1068.2.1 Overview 1068.2.2 SWOT Analysis 1078.3 NAV4694 (Navidea Biopharmaceuticals) 1088.3.1 Overview 1088.3.2 SWOT Analysis 1098.4 [18F]flutemetamol (GE Healthcare) 1098.4.1 Overview 1098.4.2 SWOT Analysis 1108.5 [18F]florbetaben (Piramal Imaging) 1118.5.1 Overview 1118.5.2 SWOT Analysis 1118.6 REDECTANE (Wilex) 1128.6.1 Overview 1128.6.2 SWOT Analysis 1139 Current and Future Players 1149.1 Overview 1149.2 Navidea Biopharmaceuticals 1159.2.1 Overview 1159.2.2 Portfolio Assessment 1159.2.3 SWOT Analysis 1189.3 Lantheus Medical Imaging 1199.3.1 Overview 1199.3.2 Portfolio Assessment 1199.3.3 SWOT Analysis 1219.4 Mallinckrodt Pharmaceuticals 1229.4.1 Overview 1229.4.2 Portfolio Assessment 1229.4.3 SWOT Analysis 1249.5 Avid Radiopharmaceuticals (Eli Lilly) 1249.5.1 Overview 1249.5.2 Portfolio Assessment 125

9.5.3 SWOT Analysis 1279.6 Bracco Imaging 1289.6.1 Overview 1289.6.2 Portfolio Assessment 1289.6.3 Product Recalls 1299.6.4 SWOT Analysis 1309.7 GE Healthcare 1309.7.1 Overview 1309.7.2 Portfolio Assessment 1319.7.3 SWOT Analysis 1339.8 Piramal Imaging 1349.8.1 Overview 1349.8.2 Portfolio Assessment 1349.8.3 SWOT Analysis 1359.9 Siemens 1359.9.1 Overview 1359.9.2 Portfolio Assessment 1359.9.3 SWOT Analysis 1379.10 Novelos Therapeutics 1379.10.1 Overview 1379.10.2 Portfolio Assessment 1389.10.3 SWOT Analysis 1399.11 Affibody 1399.11.1 Overview 1399.11.2 Portfolio Assessment 1399.11.3 SWOT Analysis 1409.12 Atreus Pharmaceuticals 1419.12.1 Overview 1419.12.2 Portfolio Assessment 1419.12.3 SWOT Analysis 1429.13 Kereos 1429.13.1 Overview 1429.13.2 Portfolio Assessment 1429.13.3 SWOT Analysis 1439.14 Progenics Pharmaceuticals 1439.14.1 Overview 1439.14.2 Portfolio Assessment 1439.14.3 SWOT Analysis 1459.15 FluoroPharma Medical 1459.15.1 Overview 1459.15.2 Portfolio Assessment 145

9.15.3 SWOT analysis 1479.16 Wilex 1479.16.1 Overview 1479.16.2 Portfolio Assessment 1489.16.3 SWOT analysis 1499.17 Radiopharmaceutical Suppliers and Distributors 1509.17.1 Supply-Chain Overview 1509.17.2 Nordion 1519.17.3 Positron 1529.17.4 Cardinal Health 1539.17.5 Advanced Accelerator Applications (AAA) 1549.18 Other Companies 1569.19 Key Deals, Partnerships, and Agreements 15710 Appendix 15810.1 Bibliography 15810.2 Definitions 17310.3 Abbreviations 17410.4 Research Methodology 17710.4.1 Overview 17710.4.2 Coverage 17710.4.3 Secondary Research 17810.5 Physicians and Specialists Included in this Study 17910.6 Primary Research 18010.7 About the Authors 18110.7.1 Analysts 18110.7.2 Global Head of Healthcare 18210.8 Disclaimer 183

1.1 List of Tables

Table 1: Desired Characteristics of an MI Probe 21Table 2: PET SWOT Analysis, 2013 29Table 3: SPECT SWOT Analysis, 2013 31Table 4: CT SWOT Analysis, 2013 33Table 5: MRI SWOT Analysis, 2013 35Table 6: Ultrasound Imaging SWOT Analysis, 2013 37Table 7: Applications of MI 39Table 8: Role of Biomarkers in Drug Development 56Table 9: Molecular Imaging – Drivers and Barriers, 2013 58Table 10: Small Molecules SWOT Analysis, 2013 75Table 11: Agent Profile of [18F]FDG 78Table 12: [18F]FDG SWOT Analysis, 2013 78Table 13: Agent Profile of [18F]FLT 81Table 14: [18F]FLT SWOT Analysis, 2013 81Table 15: Agent Profile of [18F]FMISO 84Table 16: [18F]FMISO SWOT Analysis, 2013 84Table 17: Agent Profile of [18F]FAZA 87Table 18: [18F]FAZA SWOT Analysis, 2013 87Table 19: Agent Profile of [18F]FDOPA 89Table 20: [18F]FDOPA SWOT Analysis, 2013 90Table 21: Agent Profile of [18F]NaF 92Table 22: [18F]NaF SWOT Analysis, 2013 93Table 23: Agent Profile of [11C]Acetate 95Table 24: [11C]Acetate SWOT Analysis, 2013 96Table 25: Agent Profile of [11C]PiB 98Table 26: [11C]PiB SWOT Analysis, 2013 99Table 27: Peptides SWOT Analysis, 2013 100Table 28: Nanoparticles SWOT Analysis, 2013 102Table 29: Engineered Proteins SWOT Analysis, 2013 104Table 30: Aptamers SWOT Analysis, 2013 105Table 31: [18F]flurpiridaz SWOT Analysis, 2013 107Table 32: NAV4694 SWOT Analysis, 2013 109Table 33: [18F]flutemetamol SWOT Analysis, 2013 110Table 34: [18F]florbetaben SWOT Analysis, 2013 111Table 35: REDECTANE SWOT Analysis, 2013 113Table 36: Navidea Biopharmaceuticals' Portfolio Assessment, 2013 117Table 37: Navidea Biopharmaceuticals SWOT Analysis, 2013 118Table 38: Lantheus Medical Imaging Portfolio Assessment, 2013 120Table 39: Lantheus Medical Imaging SWOT Analysis, 2013 121Table 40: Mallinckrodt Pharmaceuticals Portfolio Assessment, 2013 123Table 41: Mallinckrodt Pharmaceuticals SWOT Analysis, 2013 124Table 42: Avid Radiopharmaceuticals Portfolio Assessment, 2013 126Table 43: Avid Radiopharmaceuticals SWOT Analysis, 2013 127

Table 44: Bracco Imaging Portfolio Assessment, 2013 129Table 45: Bracco Imaging SWOT Analysis, 2013 130Table 46: GE Healthcare Portfolio Assessment, 2013 132Table 47: GE Healthcare SWOT Analysis, 2013 133Table 48: Piramal Imaging Portfolio Assessment, 2013 134Table 49: Piramal Imaging SWOT Analysis, 2013 135Table 50: Siemens Portfolio Assessment, 2013 136Table 51: Siemens SWOT Analysis, 2013 137Table 52: Novelos Therapeutics Portfolio Assessment, 2013 138Table 53: Novelos Therapeutics SWOT Analysis, 2013 139Table 54: Affibody Portfolio Assessment, 2013 140Table 55: Affibody SWOT Analysis, 2013 140Table 56: Atreus Pharmaceuticals Portfolio Assessment, 2013 141Table 57: Atreus Pharmaceuticals SWOT Analysis, 2013 142Table 58: Kereos Portfolio Assessment, 2013 142Table 59: Kereos SWOT Analysis, 2013 143Table 60: Progenics Portfolio Assessment, 2013 144Table 61: Progenics Pharmaceuticals SWOT Analysis, 2013 145Table 62: FluoroPharma Medical Portfolio Assessment, 2013 146Table 63: FlouroPharma Medical SWOT Analysis, 2013 147Table 64: Wilex Portfolio Assessment, 2013 148Table 65: Wilex SWOT Analysis, 2013 149Table 66: Nordion SWOT Analysis, 2013 151Table 67: Positron SWOT Analysis, 2013 152Table 68: Cardinal Health SWOT Analysis, 2013 154Table 69: AAA SWOT Analysis, 2013 155Table 70: Other Companies in the MI Market, 2013 156Table 71: Other Key Events in the Molecular Imaging Market 157

1.2 List of Figures

Figure 1: Components of an MI Probe 20Figure 2: Imaging Modalities 23Figure 3: Siemens Biograph TruePoint PET/CT Scanner 26Figure 4: GE Healthcare's Discovery NM/CT 670 SPECT/CT Scanner 31Figure 5: Philips' Brilliance iCT CT Scanner 32Figure 6: Toshiba Medical Systems' Vantage Titan 3T MRI Scanner 34Figure 7: Hitachi Preirus Ultrasound Scanner 36Figure 8: Imaging Applications in Drug Discovery and Development 57Figure 9: Categories of Imaging Probes 73Figure 10: Molecular Structure of [18F]FDG 76Figure 11: Whole-Body PET Scan Using [18F]FDG 77Figure 12: Molecular Structure of [18F]FLT 79Figure 13: PET Scan Using [18F]FLT 80Figure 14: Molecular Structure of [18F]FMISO 82Figure 15: CT Scan (A), PET/CT Using [18F]FDG (B), and PET/CT Scan Using [18F]FMISO (C) 83Figure 16: Molecular Structure of [18F]FAZA 85Figure 17: [18F]FAZA-PET Scan 86Figure 18: Molecular Structure of [18F]FDOPA 88Figure 19: MRI Scan (Left) and [18F]FDOPA-PET Scan (Right) 89Figure 20: Molecular structure of NaF 91Figure 21: [18F]NaF-PET Bone Scan 92Figure 22: Molecular Structure of [11C]Acetate 94Figure 23: Comparison of Enhanced CT (A) with [18F]FDG-PET (B) and [11C]Acetate PET (C) 95Figure 24: Molecular Structure of [11C]PiB 97Figure 25: Comparison of [11C]PiB-PET Scans in Subjects with AD and Control Group 98Figure 26: Supply Chain for Medical Isotopes 150

Companies Mentioned

Navidea BiopharmaceuticalsLantheus Medical ImagingMallinckrodt PharmaceuticalsAvid Radiopharmaceuticals (Eli Lilly)Bracco Imaging GE Healthcare Piramal Imaging Siemens Novelos TherapeuticsAffibody Atreus PharmaceuticalsKereos Progenics Pharmac

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