A new analysis of an important trial of the blood pressure-lowering procedure, renal denervation, shows that the main results may have been affected by a number of confounding factors that partially explain the unexpected blood pressure responses in patients. The analysis, published in the European Heart Journal, identified factors in the SYMPLICITY HTN-3 trial, such as variations in the way the procedure was performed and changes in patients’ medications and drug adherence, which may have had a significant impact on the results.
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