Fourteen years after the attack on the World Trade Center (WTC), a case study in the current issue of Annals of Global Health identifies several elements that have had a critical impact on the evolution of the WTC response and, directly or indirectly, on the health of the WTC-exposed population. The case study also recounts and assesses post-disaster monitoring efforts, recent scientific findings from the World Trade Center Health Program (WTCHP), and explores the implications of these experiences for ongoing and future environmental disaster response.